03BSAFETY SIGNAL ANALYTICS

Structuring safety questions
for analysis

Each case begins by clearly defining the exposure, comparator, adverse event, and scope. The portfolio is structured to accommodate validated findings as they become available.

PORTFOLIO NOTE

The entries below are analytical topics. They do not present unvalidated estimates or causal conclusions.

01

Drug combination

EXPOSURE / COMPARISON

Triple Whammy

REPORTED EVENT

Acute Kidney Injury

Case framework

02

Drug class

EXPOSURE / COMPARISON

SGLT2 Inhibitors

REPORTED EVENT

Diabetic Ketoacidosis

Case framework

03

Comparative signal

EXPOSURE / COMPARISON

DHP Calcium Channel Blockers

REPORTED EVENT

Peripheral Edema

Case framework

04

Drug class

EXPOSURE / COMPARISON

Sulfonylureas

REPORTED EVENT

Hypoglycemia

Case framework

05

Comparative signal

EXPOSURE / COMPARISON

Vancomycin vs Piperacillin/Tazobactam

REPORTED EVENT

DRESS

Case framework

06

Drug combination

EXPOSURE / COMPARISON

Losartan + Spironolactone

REPORTED EVENT

Alopecia

Case framework

07

Drug class

EXPOSURE / COMPARISON

Statins

REPORTED EVENT

Rhabdomyolysis

Case framework

RX PHARMALOGUE ANALYTICA

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